bwin必赢细胞与基因技术研究院特聘副教授，遗传学博士。本科毕业于吉林大学，博士毕业于中国科学院北京基因组研究所，之后在加州大学旧金山分校进行博士后训练。长期从事疾病的表观调控机制研究，在PNAS等杂志发表学术论文20篇，其中作为第一/通讯作者（含共同）10篇。曾获得美国多发性硬化症协会博士后奖学金，并多次获得论坛教育资助。课题组将整合遗传学，组学，分子生物学、细胞生物学和计算生物学等多学科的技术手段，深入解析自身免疫性疾病的遗传和表观遗传机制，开发疾病早期诊断的表观遗传学生物标志物，并为临床治疗提供新靶点。

1. 自身免疫性疾病的表观遗传调控

2. 自身免疫性疾病的表观遗传生物标志物和治疗方法的研究

学习经历：

2012.09-2018.01：中国科学院大学北京基因组研究所，遗传学专业，博士，导师：慈维敏教授

2008.09-2012.07：吉林大学，生物工程专业，学士

工作经历：

2025.08-至今，bwin必赢，细胞与基因技术研究院，特聘副教授

2023.12-2025.06，加州大学旧金山分校，助理研究员

2019.01-2023.11，加州大学旧金山分校，博士后

2018.01-2018.12，中国科学院北京基因组研究所，助理研究员

1.ACTRIMS论坛2023，美国加利福尼亚州圣地亚哥，2023年（海报展示)；

2.ACTRIMS论坛2022，美国佛罗里达州西棕榈滩，2022年（海报展示）；

3.第九届Tykeson学者会议，美国得克萨斯州达拉斯，2022年（口头报告）；

4.细胞生物学2022会议（ASCB与EMBO联合举办），美国华盛顿特区，2022年（海报展示）。

科研项目：

1. 美国多发性硬化症学会博士后奖学金，2022.07-2025.06，结题，主持

2. 美国国立卫生研究院R01基金， 2023.05-2027.04，博后，重要参与者

代表性论文：

1.Ma Q, Caillier SJ, Muzic S, University of California San Francisco MS-EPIC Team, Wilson MR, Henry RG, Cree BAC, Hauser SL, Didonna A, Oksenberg JR. Specific hypomethylation programs underpin B cell activation in early multiple sclerosis. Proc Natl Acad Sci U S A. 2021; 118(51).

2.Ma Q, Matsunaga A, Ho B, Oksenberg JR, Didonna A. Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020; 17(1):297.

3.Ma Q, Shams H, Didonna A, Baranzini SE, Cree BAC, Hauser SL, Henry RG, Oksenberg JR. Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes. Commun Biol. 2023; 6(1):342.

4.Ma Q, Augusto DG, Montero-Martin G, Caillier SJ, Osoegawa K, Cree BAC, Hauser SL, Didonna A, Hollenbach JA, Norman PJ, Fernandez-Vina M, Oksenberg JR. High-resolution DNA methylation screening of the major histocompatibility complex in multiple sclerosis. Front Neurol. 2023; 14:1326738.

5.Ma Q, Didonna A. Ataxin-1 controls the expression of specific noncoding RNAs in B cells upon autoimmune demyelination. Immunol Cell Biol. 2023; 101(4):358-367.

6.Ma Q, Oksenberg JR, Didonna A. Epigenetic control of ataxin-1 in multiple sclerosis. Ann Clin Transl Neurol. 2022; 9(8):1186-1194.

7.Ma Q, Didonna A. The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells. Mol Brain. 2021; 14(1):19.

8.Ma Q, Wang J, Qi J, Peng D, Guan B, Zhang J, Li Z, Zhang H, Li T, Shi Y, Li X, Zhou L, Chen K, Ci W. Increased chromosomal instability characterizes metastatic renal cell carcinoma. Transl Oncol. 2021; 14(1):100929.

9.Ma Q, Xu Z, Lu H, Xu Z, Zhou Y, Yuan B, Ci W. Distal regulatory elements identified by methylation and hydroxymethylation haplotype blocks from mouse brain. Epigenetics & Chromatin. 2018; 11(1):75.

10.Ma Q, Lu H, Xu Z, Zhou Y, Ci W. Mouse olfactory bulb methylome and hydroxymethylome maps reveal noncanonical active turnover of DNA methylation. Epigenetics. 2017; 12(8):708-714.

11.Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N, University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR. Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans. Brain. 2023; 146(2):645-656.

12.Shams H, Matsunaga A, Ma Q, Mofrad MRK, Didonna A. Methylation at a conserved lysine residue modulates tau assembly and cellular functions. Mol Cell Neurosci. 2022; 120:103707.

13.Didonna A, Canto Puig E, Ma Q, Matsunaga A, Ho B, Caillier SJ, Shams H, Lee N, Hauser SL, Tan Q, Zamvil SS, Oksenberg JR. Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis. Proc Natl Acad Sci U S A. 2020; 117(38):23742-23750.

14.Zhang Y, Li Y, Li T, Shen X, Zhu T, Tao Y, Li X, Wang D, Ma Q, Hu Z, Liu J, Ruan J, Cai J, Wang HY, Lu X. Genetic Load and Potential Mutational Meltdown in Cancer Cell Populations. Mol Biol Evol. 2019; 36(3):541-552.

15.Peng D, Ge G, Xu Z, Ma Q, Shi Y, Zhou Y, Gong Y, Xiong G, Zhang C, He S, He Z, Li X, Ci W, Zhou L. Diagnostic and prognostic biomarkers of common urological cancers based on aberrant DNA methylation. Epigenomics. 2018; 10(9):1189-1199.

16.Xu J, Peng X, Chen Y, Zhang Y, Ma Q, Liang L, Carter AC, Lu X, Wu CI. Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity. Elife. 2017; 6.

17.Zhang C, Yang L, Ding Y, Wang Y, Lan L, Ma Q, Chi X, Wei P, Zhao Y, Steinbüchel A, Zhang H, Liu P. Bacterial lipid droplets bind to DNA via an intermediary protein that enhances survival under stress. Nat Commun. 2017; 8:15979.

18.Wang K, Ma Q, Jiang L, Lai S, Lu X, Hou Y, Wu CI, Ruan J. Ultra-precise detection of mutations by droplet-based amplification of circularized DNA. BMC Genomics. 2016; 17:214.

19.Chen K, Zhang J, Guo Z, Ma Q, Xu Z, Zhou Y, Xu Z, Li Z, Liu Y, Ye X, Li X, Yuan B, Ke Y, He C, Zhou L, Liu J, Ci W. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. Cell Res. 2016; 26(1):103-18.

20.Cheng QY, Xiong J, Huang W, Ma Q, Ci W, Feng YQ, Yuan BF. Sensitive Determination of Onco-metabolites of D- and L-2-hydroxyglutarate Enantiomers by Chiral Derivatization Combined with Liquid Chromatography/Mass Spectrometry Analysis. Sci Rep. 2015; 5:15217.